Quantitative microscopy of hepatic changes induced by phenethyl isothiocyanate in Fischer-344 rats fed either a cereal-based diet or a purified diet. Toxicol Pathol 1995;23(6):644-52
Date
11/01/1995Pubmed ID
8772250DOI
10.1177/019262339502300602Scopus ID
2-s2.0-0029590752 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
Hepatic changes induced by phenethyl isothiocyanate (PEITC) in the liver of rats were determined by quantitative microscopy. Groups of male Fischer-344 rats were fed either a standard, cereal-based diet (Wayne rodent meal) or a purified diet (AIN-76A) containing PEITC at concentrations of 0.75 and 6.0 mmol/kg for 13 wk. Severe hepatic lipidosis was observed in control rats fed the purified diet. Addition of PEITC to the purified diet significantly reduced lipid content in hepatocytes. In contrast, lipid content in the liver of the rats fed the cereal-based diet containing PEITC was greater than in control rats maintained on the same diet. In addition, dose-related reductions in hepatocyte, lipid droplet, peroxisome, and mitochondrial volumes were observed in PEITC-treated rats fed the cereal-based diet. These results indicate that PEITC exerts differential effects on the liver of rats fed either the cereal-based or purified diet.
Author List
Gray RH, Adam-Rodwell GA, Maris D, Haskins JR, Stoner GDMESH terms used to index this publication - Major topics in bold
AnimalsAnticarcinogenic Agents
Cell Count
Cell Nucleus
Diet
Edible Grain
Isothiocyanates
Lipid Metabolism
Lipids
Liver
Male
Microbodies
Mitochondria, Liver
Rats
Rats, Inbred F344
