Faculty Collaboration Database

Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells. Biochim Biophys Acta 2011 Oct;1812(10):1301-13

Date

10/21/2010

Pubmed ID

20959142

Pubmed Central ID

PMC3038174

DOI

10.1016/j.bbadis.2010.10.004

Scopus ID

2-s2.0-80052268963 (requires institutional sign-in at Scopus site)   60 Citations

Abstract

Members of the epidermal growth factor (EGF) family bind to ErbB (EGFR) family receptors which play an important role in the regulation of various fundamental cell processes including cell proliferation and differentiation. The normal rodent kidney has been shown to express at least three members of the ErbB receptor family and is a major site of EGF ligand synthesis. Polycystic kidney disease (PKD) is a group of diseases caused by mutations in single genes and is characterized by enlarged kidneys due to the formation of multiple cysts in both kidneys. Tubule cells proliferate, causing segmental dilation, in association with the abnormal deposition of several proteins. One of the first abnormalities described in cell biological studies of PKD pathogenesis was the abnormal mislocalization of the EGFR in cyst lining epithelial cells. The kidney collecting duct (CD) is predominantly an absorptive epithelium where electrogenic Na(+) entry is mediated by the epithelial Na(+) channel (ENaC). ENaC-mediated sodium absorption represents an important ion transport pathway in the CD that might be involved in the development of PKD. A role for EGF in the regulation of ENaC-mediated sodium absorption has been proposed. However, several investigations have reported contradictory results indicating opposite effects of EGF and its related factors on ENaC activity and sodium transport. Recent advances in understanding how proteins in the EGF family regulate the proliferation and sodium transport in normal and PKD epithelial cells are discussed here. This article is part of a Special Issue entitled: Polycystic Kidney Disease.

Author List

Zheleznova NN, Wilson PD, Staruschenko A

MESH terms used to index this publication - Major topics in bold

Animals
Cell Proliferation
Epidermal Growth Factor
Epithelial Cells
Epithelial Sodium Channels
ErbB Receptors
Humans
Ion Transport
Kidney
Models, Biological
Polycystic Kidney Diseases
Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Autosomal Recessive
Sodium
TRPP Cation Channels