Foodstuffs for preventing cancer: the preclinical and clinical development of berries. Cancer Prev Res (Phila) 2009 Mar;2(3):187-94
Date
03/05/2009Pubmed ID
19258544Pubmed Central ID
PMC2769015DOI
10.1158/1940-6207.CAPR-08-0226Scopus ID
2-s2.0-68349114819 (requires institutional sign-in at Scopus site) 140 CitationsAbstract
Laboratory research involving berries is a promising example of food-based cancer prevention. Berries contain many known chemopreventive agents such as anthocyanins and ellagitannins that can be greatly concentrated in freeze-dried berry powders. Based on our program of berry research, this commentary presents the first reported stepwise scheme for the preclinical and clinical development of foodstuffs for cancer prevention. Our preclinical work within this scheme includes promising approaches for assessing the chemopreventive potential of berry powder and berry extracts in preclinical model systems, for determining the mechanisms of action of these agents, and for identifying the active constituents in berries. The commentary also presents preliminary results of clinical trials in the oral cavity, esophagus, and colon using various formulations of freeze-dried berries. The relative merits of berry powders, extracts, or individual constituents (anthocyanins) for cancer prevention are also discussed.
Author List
Stoner GDMESH terms used to index this publication - Major topics in bold
AnimalsAnthocyanins
Anticarcinogenic Agents
Clinical Trials as Topic
Diet
Drug Screening Assays, Antitumor
Esophagus
Food
Fruit
Humans
Mice
Neoplasms
Neoplasms, Experimental
Plant Extracts
Rats
