Inhibition of ornithine decarboxylase induces embryonal carcinoma cell differentiation. Biochem Biophys Res Commun 1983 Jul 18;114(1):410-7
Date
07/18/1983Pubmed ID
6411082DOI
10.1016/0006-291x(83)91642-xScopus ID
2-s2.0-0020966292 (requires institutional sign-in at Scopus site) 45 CitationsAbstract
Murine embryonal carcinoma cells can be induced to differentiate in vitro by various physical and chemical means. We report here that inhibition of ornithine decarboxylase activity with a specific enzyme-activated inhibitor, alpha-difluoromethylornithine, can induce differentiation in embryonal carcinoma cells. The differentiated phenotype can be distinguished from undifferentiated embryonal carcinoma cells by altered cellular morphology, biochemical and cell surface antigenic properties. These results suggest that alterations in the levels of cellular polyamines may play a role in embryonal carcinoma cell differentiation.
Author List
Schindler J, Kelly M, McCann PPMESH terms used to index this publication - Major topics in bold
AnimalsCarboxy-Lyases
Cell Differentiation
Cell Line
Eflornithine
Mice
Neoplasms, Experimental
Ornithine
Ornithine Decarboxylase Inhibitors
Putrescine
Spermidine
Spermine
Teratoma
