Nevus simplex: a reconsideration of nomenclature, sites of involvement, and disease associations. J Am Acad Dermatol 2010 Nov;63(5):805-14
Date
08/24/2010Pubmed ID
20728246DOI
10.1016/j.jaad.2009.08.066Scopus ID
2-s2.0-77958001707 (requires institutional sign-in at Scopus site) 39 CitationsAbstract
BACKGROUND: Nevus simplex (NS) is a common birthmark on the forehead, glabella, upper eyelids, and nape. More widespread involvement can be confused with port-wine stains (nevus flammeus) and other vascular birthmarks.
OBJECTIVES: To further categorize the anatomic locations in infants with extensive NS and evaluate for any possible disease associations.
METHODS: We conducted a retrospective review of patients with extensive NS seen at two tertiary care centers.
RESULTS: Twenty-seven patients with extensive NS were identified. All had at least one typical site of involvement: glabella (77.8%), nape (59.3%), and eyelids (55.6%). Additional sites were the scalp, including the vertex, occiput, parietal (66.7%); nose (66.7%); lip (59.2%); lumbosacral skin (55.6%); and upper and mid back (14.8 %).
LIMITATIONS: Retrospective nature of the study and relatively small sample size.
CONCLUSIONS: We propose the term "nevus simplex complex" for NS with more widespread involvement beyond the typical sites. Consistent use of the term "nevus simplex" will aid in correct diagnosis and appropriate management of these birthmarks.
Author List
Juern AM, Glick ZR, Drolet BA, Frieden IJMESH terms used to index this publication - Major topics in bold
BackBeckwith-Wiedemann Syndrome
Child, Preschool
Face
Female
Hemangioma, Capillary
Humans
Incidence
Infant
Infant, Newborn
Male
Nevus
Retrospective Studies
Scalp
Skin Neoplasms
Terminology as Topic
