Hypoxic fractions of human tumors xenografted into mice: a review. Int J Radiat Oncol Biol Phys 1990 Jul;19(1):197-202
Date
07/01/1990Pubmed ID
2143178DOI
10.1016/0360-3016(90)90154-cScopus ID
2-s2.0-0025328583 (requires institutional sign-in at Scopus site) 109 CitationsAbstract
Transplanted tumors in rats and mice have been used extensively in radiobiology studies examining the biological basis and therapeutic implications of hypoxia in solid tumors, and in studies evaluating new agents and regimens which may circumvent the radioprotective effects of hypoxic cells. This use of rodent tumors assumes that data obtained using rapidly-growing transplanted tumors arising in inbred rodents can be extrapolated meaningfully to the treatment of primary and/or metastatic lesions in heterozygous humans. The studies reported here examine one facet of this critical assumption by comparing the hypoxic fractions of transplanted rodent tumors with those of human tumor cell lines xenografted into immune deficient mice. No significant differences were found between the hypoxic fractions of the xenografts and those of mouse tumors. This finding eliminates several possible bases for predicting that the oxygenation of human tumors might be systematically different from that of the rodent tumors often used in preclinical radiobiology studies, and supports the hypothesis that human tumors contain hypoxic cells which may be critical in determining their response to therapy.
Author List
Rockwell S, Moulder JEMESH terms used to index this publication - Major topics in bold
AnimalsCell Division
Cell Hypoxia
Disease Models, Animal
Humans
Meta-Analysis as Topic
Mice
Neoplasm Transplantation
Neoplasms, Experimental
Radiobiology
Transplantation, Heterologous
Tumor Cells, Cultured
