Tissue self-affinity and polarized light scattering in the born approximation: a new model for precancer detection. Phys Rev Lett 2006 Sep 29;97(13):138102
Date
10/10/2006Pubmed ID
17026078DOI
10.1103/PhysRevLett.97.138102Scopus ID
2-s2.0-33749345999 (requires institutional sign-in at Scopus site) 121 CitationsAbstract
Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.
Author List
Hunter M, Backman V, Popescu G, Kalashnikov M, Boone CW, Wax A, Gopal V, Badizadegan K, Stoner GD, Feld MSMESH terms used to index this publication - Major topics in bold
AlgorithmsAnimals
Biomarkers, Tumor
Carcinogens
Equipment Design
Esophageal Neoplasms
Esophagus
Humans
Image Interpretation, Computer-Assisted
Light
Mass Screening
Models, Statistical
Neoplasms
Rats
Scattering, Radiation
