The molecular biology of polycystic kidney disease. Pediatr Nephrol 1998 Nov;12(9):721-6
Date
01/05/1999Pubmed ID
9874315DOI
10.1007/s004670050534Scopus ID
2-s2.0-0031790118 (requires institutional sign-in at Scopus site) 25 CitationsAbstract
In recent years there have been a number of developments in polycystic kidney disease (PKD) research. The genes associated with the predominant forms of autosomal dominant PKD have been cloned, and the gene associated with a mouse model for autosomal recessive PKD has been identified and characterized. Other studies have yielded new information regarding the role of the epidermal growth factor receptor gene in promoting renal cyst formation. In this review article we summarize recent published data on the molecular genetics of autosomal dominant and autosomal recessive PKD and provide a working model of how multiple genes participate in the PKD disease pathway.
Author List
Murcia NS, Woychik RP, Avner EDAuthor
Ellis D. Avner MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsErbB Receptors
Humans
Membrane Proteins
Mice
Polycystic Kidney Diseases
Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Autosomal Recessive
Proteins
TRPP Cation Channels
Tumor Suppressor Proteins
