Faculty Collaboration Database

Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens. Toxicol Pathol 1991;19(2):168-75

Date

01/01/1991

Pubmed ID

1771369

DOI

10.1177/019262339101900212

Scopus ID

2-s2.0-0025881286 (requires institutional sign-in at Scopus site)   39 Citations

Abstract

The histogenesis of mouse lung adenomas is currently being investigated in several laboratories. Based upon studies of a limited number of carcinogens in different mouse strains, some investigators suggest that all lung adenomas in mice are derived from alveolar type II cells, whereas others suggest a Clara cell origin for a majority of the tumors. This report differs from previous investigations in that 12 different carcinogens were evaluated for the types of lung tumor growth patterns they induced in a single mouse strain (strain A mice). The carcinogens aflatoxin B1 (AFB1), benzo(a)pyrene (BP), 1,2-dimethylhydrazine (DMH), 3-methylcholanthrene (MCA), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and N-nitrosomethylurea (MNU) induced tumors with a predominantly solid/alveolar growth pattern, whereas N-nitrosodiethylamine (NDEA) induced predominantly papillary tumors. Most of the other carcinogens induced a higher proportion of lung tumors with the solid/alveolar growth pattern than with the papillary growth pattern; however, ratios between the 2 growth patterns varied. If, as suggested by others, solid tumors are derived from alveolar type II cells and papillary tumors from Clara cells, then carcinogens may differ with respect to their ability to transform one cell type or the other.

Author List

Gunning WT, Castonguay A, Goldblatt PJ, Stoner GD

MESH terms used to index this publication - Major topics in bold

1,2-Dimethylhydrazine
Adenoma
Aflatoxins
Animals
Benzo(a)pyrene
Carcinogens
Cell Transformation, Neoplastic
Diethylnitrosamine
Dimethylhydrazines
Lung Neoplasms
Methylcholanthrene
Methylnitrosourea
Mice
Mice, Inbred A
Microscopy, Electron
Nitrosamines