Faculty Collaboration Database

Inhibition of N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats by ellagic acid. Carcinogenesis 1990 Jan;11(1):55-61

Date

01/01/1990

Pubmed ID

2295128

DOI

10.1093/carcin/11.1.55

Scopus ID

2-s2.0-0025037968 (requires institutional sign-in at Scopus site)   182 Citations

Abstract

In this report, we describe the ability of ellagic acid (EA), a phenolic compound present in a number of fruits and nuts, to inhibit N-nitrosobenzylmethylamine (NBMA) tumorigenesis in the rat esophagus. When administered in a semi-purified diet at concentrations of 0.4 and 4 g/kg, EA produced a significant (21-55%) decrease in the average number of NBMA-induced esophageal tumors after 20 and 27 weeks of the bioassay. EA exhibited inhibitory effects toward preneoplastic lesions as well as neoplastic lesions. Tumors were not observed in vehicle-control rats or in rats that received EA alone.

Author List

Mandal S, Stoner GD

MESH terms used to index this publication - Major topics in bold

Animals
Antineoplastic Agents
Benzopyrans
Dimethylnitrosamine
Ellagic Acid
Esophageal Neoplasms
Esophagus
Male
Rats
Rats, Inbred F344