A child with valproic acid-associated carnitine deficiency and carnitine-responsive cardiac dysfunction. J Child Neurol 1992 Oct;7(4):413-6
Date
10/01/1992Pubmed ID
1281852DOI
10.1177/088307389200700416Scopus ID
2-s2.0-0026448556 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Valproic acid enhances renal losses of carnitine esters and leads to decreased plasma free carnitine concentrations in many patients receiving valproic acid therapy. However, decreased serum carnitine levels are of unclear pathologic significance, and most children manifest no symptoms of carnitine deficiency. We report a child with valproic acid-associated carnitine deficiency who had severe cardiac dysfunction develop that resolved with carnitine replacement therapy.
Author List
Bratton SL, Garden AL, Bohan TP, French JW, Clarke WRMESH terms used to index this publication - Major topics in bold
CarnitineChild
Developmental Disabilities
Heart Diseases
Humans
Male
Metabolic Diseases
Myocardium
Valproic Acid
