Quantitative trait loci mapping. Methods Mol Biol 2008;455:203-35
Date
05/09/2008Pubmed ID
18463822DOI
10.1007/978-1-59745-104-8_16Scopus ID
2-s2.0-84934441488 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
This chapter presents current methods for mapping quantitative trait loci (QTLs) in natural populations especially in humans. We discussed the experimental designs for QTL mapping, traditional methods adopted such as linkage mapping approaches and methods for linkage disequilibrium (LD) mapping. Multiple traits and interaction analysis are also outlined. The application of modern genomic approaches, which mainly exploit the microarray technology, into QTL mapping was detailed. The latter are very recent protocols and are less developed than linkage and association methods at present. The main focus of this chapter is technical issues although statistical issues are also covered to certain extent. Finally, we summarize the limitations of the current QTL approaches and discuss the solutions to certain problems.
Author List
Xiong DH, Liu JF, Guo YF, Guo Y, Yang TL, Jiang H, Chen Y, Yang F, Recker RR, Deng HWMESH terms used to index this publication - Major topics in bold
Chromosome MappingEpistasis, Genetic
Genetic Linkage
Genome, Human
Haplotypes
Humans
Linkage Disequilibrium
Models, Genetic
Oligonucleotide Array Sequence Analysis
Pedigree
Quantitative Trait Loci
Quantitative Trait, Heritable
