Adamantinoma with plasmacytoid features: expanding the spectrum of a diagnostically challenging entity. Ann Diagn Pathol 2011 Oct;15(5):347-54
Date
10/19/2010Pubmed ID
20952283DOI
10.1016/j.anndiagpath.2010.04.007Scopus ID
2-s2.0-80052864102 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Adamantinoma is a rare neoplasm that characteristically involves the tibia. In many instances, typical location within the tibia, very slow course, and a typical radiographic appearance can strongly suggest the correct diagnosis. We present a case that has both unusual radiographic findings and uncharacteristic histology. In this case, radiologic imaging showed a poorly defined lytic lesion within the distal, lateral tibia extending to the joint with central necrosis, overlying periosteal reaction and possible tumor spread into soft tissue. The histology of this lesion showed pronounced vascularity and surrounding large neoplastic cells with plasmacytoid morphology. The combination of these features led to an initial misdiagnosis as metastatic carcinoma from unknown primary.
Author List
Walters MP, Baynes K, Carrera GF, King DM, Wang D, Charlson J, Zambrano EAuthors
Keith E. Baynes MD Adjunct Associate Professor in the Radiology department at Medical College of WisconsinGuillermo Carrera MD Emeritus Professor in the Radiology department at Medical College of Wisconsin
John A. Charlson MD Associate Professor in the Medicine department at Medical College of Wisconsin
David M. King MD Chair, Professor in the Orthopaedic Surgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdamantinomaAdult
Biomarkers, Tumor
Carcinoma
Diagnosis, Differential
Gastrointestinal Neoplasms
Humans
Immunohistochemistry
Male
Plasma Cells
Radiography
Tibia
