Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression. Exp Lung Res 2007;33(8-9):385-417
Date
11/13/2007Pubmed ID
17994369DOI
10.1080/01902140701703226Scopus ID
2-s2.0-36248930984 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Fibroblast growth factor-7 (FGF7) is a lung epithelial cell mitogen that is cytoprotective during injury. Transgenic mice that conditionally expressed FGF7 were used to dissect the mechanisms of FGF7 protection during lung injury. FGF7 improved survival when induced 3 days prior to acute lung injury. In contrast, FGF7 caused pulmonary inflammation and lung injury after 7 days or longer. Gene expression analysis of mouse lung mRNA identified mRNAs that contribute to the protective effects of FGF7. FGF7 improved survival during acute lung injury in adult mouse lung after short-term expression, but paradoxically induced inflammation and injury after persistent expression.
Author List
Tichelaar JW, Wesselkamper SC, Chowdhury S, Yin H, Berclaz PY, Sartor MA, Leikauf GD, Whitsett JAMESH terms used to index this publication - Major topics in bold
AnimalsCytoprotection
Epithelial Cells
Fibroblast Growth Factor 7
Gene Expression Profiling
Inflammation
Lung
Mice
Mice, Transgenic
Nickel
Proteins
RNA, Messenger
Time Factors
