Endophthalmitis from Mycobacterium bovis-bacille Calmette-Guérin after intravesicular bacille Calmette-Guérin injections for bladder carcinoma. Am J Ophthalmol 1999 Nov;128(5):648-50
Date
11/30/1999Pubmed ID
10577542DOI
10.1016/s0002-9394(99)00206-8Scopus ID
2-s2.0-0032731161 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
PURPOSE: To present clinical and histologic findings of intraocular infection with Mycobacterium bovis-bacille Calmette-Guérin after intravesicular bacille Calmette-Guérin injections for treatment of bladder carcinoma.
METHODS: A 77-year-old man was initially seen with visual acuity of 20/200, focal retinitis, vasculitis, and progressive vitreous opacity in the right eye and visual acuity of light perception, intraocular inflammation, and a dense cataract in the left eye 14 months after intravesicular injection of live bacille Calmette-Guérin organisms.
RESULTS: Vitreous cultures in the right eye demonstrated growth of bacille Calmette-Guérin organisms. Bilateral loss of light perception occurred despite systemic antimy-cobacterial therapy. Histopathologic examination demonstrated nongranulomatous inflammation and acid-fast bacilli in both eyes.
CONCLUSION: Delayed endogenous endophthalmitis may develop after intravesicular bacille Calmette-Guérin injection that may not respond to systemic agents. Intravitreal therapy may be indicated.
Author List
Han DP, Simons KB, Tarkanian CN, Moretti STMESH terms used to index this publication - Major topics in bold
AgedCarcinoma
Endophthalmitis
Eye
Eye Enucleation
Humans
Injections
Male
Mycobacterium Infections
Mycobacterium bovis
Urinary Bladder Neoplasms
Vitreous Body
