Medical College of Wisconsin
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Biliary tract inflammatory disorders: primary sclerosing cholangitis and primary biliary cirrhosis. Curr Gastroenterol Rep 1999 Apr;1(2):95-101

Date

09/12/2000

Pubmed ID

10980934

DOI

10.1007/s11894-996-0006-8

Scopus ID

2-s2.0-0033107540 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are chronic progressive cholestatic diseases that frequently lead to biliary cirrhosis. The exact pathogenesis of these diseases remains elusive but is likely immunologically based. Complications range from fatigue and pruritus to end-stage liver disease. The risk of developing hepatocellular carcinoma is low for patients with PBC, whereas cholangiocarcinoma is common in PSC and carries an ominous prognosis. Although ursodeoxycholic acid is effective in slowing the progression of PBC, no effective medical therapy exists for PSC. Liver transplantation is the only option for patients with end-stage liver disease and yields excellent long-term survival in both groups.

Author List

Franco J, Saeian K

Author

Kia Saeian MD Interim Chief, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Bile Duct Neoplasms
Cholangiocarcinoma
Cholangitis, Sclerosing
Humans
Liver Cirrhosis, Biliary
Liver Transplantation
Risk Factors
Ursodeoxycholic Acid