Faculty Collaboration Database

Structural requirements for, and the effects of chemicals on, the rat pulmonary inactivation of prostaglandins. Prostaglandins 1977 Jul;14(1):51-60

Date

07/01/1977

Pubmed ID

897214

DOI

10.1016/0090-6980(77)90156-3

Scopus ID

2-s2.0-0017736247 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

We have investigated the removal of prostaglandins (PGs) from the pulmonary circulation using the isolated perfused rat lung in order to determine which parts of the PG molecule were essential for transport into the pulmonary tissue. From these studies we propse that three functional groups of the PG molecule are necessary for transport into the lung tissue: the carboxylic acid group at carbon 1, hydroxyl group at carbon 15, and an oxygen group at carbon 11. The geometrical relationship between these groups is important for transport since reduction of the 13, 14-double bond reduced transport, and changing the C-15 hydroxyl from an S to R configuration abolished transport. Various chemicals, drugs, and PG antagonists were tested for their ability to inhibit the transport system resposible for PG removal from the circulation. Diphloretin phosphate and polyphloretin phosphate were effective inhibitors, whereas dexamethasone, bromocresol green N-ethyl maleimide and imipramine were moderately effective inhibitors. The PG antagonist, SC-19220, 7-oxo-13-prostynoic acid, and hydrocortisone were ineffective.

Author List

Eling TE, Hawkins HJ, Anderson MW

MESH terms used to index this publication - Major topics in bold

Animals
Anti-Inflammatory Agents
Lung
Male
Prostaglandin Antagonists
Prostaglandins
Prostaglandins A
Prostaglandins E
Prostaglandins F
Prostaglandins, Synthetic
Pulmonary Circulation
Rats