Faculty Collaboration Database

Effects of carotid and aortic chemoreceptor denervation in newborn piglets. J Appl Physiol (1985) 2002 Mar;92(3):893-900

Date

02/14/2002

Pubmed ID

11842019

DOI

10.1152/japplphysiol.00819.2001

Scopus ID

2-s2.0-0036095611 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

The objective of the present study was to test the hypothesis that in neonatal piglets there would be no hypoventilation after sham denervation or aortic denervation (AOD) alone, but there would be transient hypoventilation after carotid body denervation (CBD) and the hypoventilation would be greatest after combined carotid and aortic denervation (CBD+AOD). There was a significant (P < 0.05) hypoventilation in CBD and CBD+AOD piglets denervated at 5, 15, and 25 days of age. The hypoventilation in CBD+AOD piglets denervated at 5 days of age was greater (P < 0.05) than that of all other groups. Conversely, sham-denervated and AOD piglets did not hypoventilate after denervation. Injections of sodium cyanide showed that aortic chemoreceptors were a site of recovery of peripheral chemosensitivity after CBD. This aortic sodium cyanide response was abolished by prior injection of a serotonin 5a receptor blocker. Residual peripheral chemosensitivity after CBD+AOD was localized to the left ventricle. We conclude that 1) aortic chemoreceptors contribute to eupneic breathing in piglets that were carotid denervated at 5 days of age and 2) there are multiple sites of residual peripheral chemosensitivity after CBD.

Author List

Serra A, Brozoski D, Hodges M, Roethle S, Franciosi R, Forster HV

Authors

Hubert V. Forster PhD Professor in the Physiology department at Medical College of Wisconsin
Matthew R. Hodges PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Animals, Newborn
Aorta
Baroreflex
Blood Pressure
Carotid Arteries
Chemoreceptor Cells
Denervation
Hypoxia
Injections, Intra-Arterial
Injections, Intravenous
Jugular Veins
Mortality
Reference Values
Respiratory Physiological Phenomena
Sodium Cyanide
Swine