[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis]. Ross Fiziol Zh Im I M Sechenova 2001 Dec;87(12):1617-25
Date
02/16/2002Pubmed ID
11845802Scopus ID
2-s2.0-0035749006 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
It has been found that stimulation of delta-1 opioid receptors by intravenous administration of DPDPE (0.5 mg/kg) decreases the incidence of ischemic and reperfusion-induced arrhythmias and also increases myocardial tolerance to the arrhythmogenic action of epinephrine in rats. Pretreatment with a selective delta-2 agonist, DSLET, had no antiarrhythmic effect. The inhibition of the enzymatic breakdown of endogenous enkephalins by intravenous administration of acetorphan decreased the incidence of epinephrine-induced arrhythmias. Pretreatment with a selective delta opioid receptor antagonist, ICI-174.868, completely abolished this antiarrhythmic effect. Adaptation of rats to repeated immobilization stress during 12 days increased myocardial tolerance to the arrhythmogenic action of coronary artery occlusion (10 min) and reperfusion (10 min). Pretreatment with a selective delta opioid receptor antagonist, TIPP(Psy), did not abolish the antiarrhythmic effect of adaptation to immobilization stress. It seems that endogenous agonists of delta opioid receptors are not involved in the antiarrhythmic effect resulting from adaptation to stress.
Author List
Naryzhnaia NV, Krylatov AV, Maslov LN, Lishmanov IuB, Gross GJ, Stephano JBMESH terms used to index this publication - Major topics in bold
Adaptation, PhysiologicalAnimals
Arrhythmias, Cardiac
Enkephalin, D-Penicillamine (2,5)-
Enkephalin, Leucine
Ligands
Male
Myocardial Reperfusion Injury
Naloxone
Naltrexone
Narcotic Antagonists
Oligopeptides
Rats
Rats, Wistar
Receptors, Opioid, delta
Tetrahydroisoquinolines
Thiorphan
