Medical College of Wisconsin
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Desacetyl vinblastine amide sulfate induced ineffective erythropoiesis. Cancer 1979 Jul;44(1):64-8

Date

07/01/1979

Pubmed ID

455265

DOI

10.1002/1097-0142(197907)44:1<64::aid-cncr2820440112>3.0.co;2-5

Scopus ID

2-s2.0-0018743855 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

Ineffective erythropoiesis occurred during desacetyl vinblastine amide sulfate (VDS) therapy of a patient with metastatic Ewing's sarcoma. The peripheral blood was characterized by anisocytosis, poikilocytosis and reticulocytopenia. Bone marrow showed megaloblastic red cell hyperplasia with nuclear fragmentation, binuclearity and abnormal metaphases. Radioiron incorporation into red cells was markedly decreased. Electron microscopy showed red cell surface changes previously called ropalocytosis. Normal erythropoiesis promptly resumed when VDS treatment was withheld. Although less common than leukopenia, red cell abnormalities are part of the spectrum of vinca alkaloid toxicity.

Author List

Jumean HG, Camitta B, Holcenberg J, Hodach A

Author

Bruce m. Camitta Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Anemia
Bone Marrow
Erythropoiesis
Humans
Male
Microscopy, Electron
Sarcoma, Ewing
Vinblastine