Adverse drug reactions affecting blood cells. Handb Exp Pharmacol 2010(196):57-76
Date
12/19/2009Pubmed ID
20020259DOI
10.1007/978-3-642-00663-0_3Scopus ID
2-s2.0-77949331493 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
Numerous medications and other xenobiotics are capable of producing adverse reactions (ADRs) affecting red cells, platelets or neutrophils. Occasionally, more than one blood element is affected simultaneously. As with all drug reactions, some side effects are a direct consequence of a known pharmacologic action of the drug and are dose-dependent; others occur sporadically and relatively independent of dose. The latter ("idiosyncratic") reactions are unpredictable and, in general, have no known underlying genetic basis. Many are antibody-mediated, as would be expected since cellular immune effector cells have little direct access to circulating blood cells. In this chapter, we will discuss idiosyncratic drug reactions affecting blood and blood forming tissues with an emphasis on those thought to be immune-mediated.
Author List
Aster RHAuthor
Richard H. Aster MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anemia, AplasticAnimals
Blood Cells
Blood Platelets
Drug-Related Side Effects and Adverse Reactions
Environmental Pollutants
Erythrocytes
Hematologic Diseases
Humans
Neutrophils
