Identification of Bakb, a new platelet-specific antigen associated with posttransfusion purpura. Blood 1988 Apr;71(4):894-8
Date
04/01/1988Pubmed ID
3355896Scopus ID
2-s2.0-0023818397 (requires institutional sign-in at Scopus site) 63 CitationsAbstract
Baka is a platelet alloantigen whose putative allele, Bakb, has not been identified previously. By using a serum, "Har," obtained from a patient with posttransfusion purpura, we describe the platelet alloantigen Bakb. The Har serum reacted with an NP-40-extractable platelet membrane protein of 142 kd with mobility similar to platelet glycoprotein IIb alpha. We found that the antigen recognized by the Har serum is inherited in an autosomal dominant mode with an apparent gene frequency of .39. Chi-square analysis of observed and expected phenotype frequencies indicated that serum Har recognizes Bakb, the anticipated allele of Baka. Our findings provide new evidence for polymorphism of glycoprotein IIb and for the association of posttransfusion purpura with alloimmunization to determinants on this glycoprotein.
Author List
Kickler TS, Herman JH, Furihata K, Kunicki TJ, Aster RHMESH terms used to index this publication - Major topics in bold
Antigens, Human PlateletBlood Platelets
Electrophoresis, Agar Gel
Electrophoresis, Polyacrylamide Gel
Female
Gene Frequency
Humans
Immunoassay
Isoantibodies
Isoantigens
Middle Aged
Phenotype
Purpura, Thrombocytopenic
