Recruitment of unrelated persons as bone marrow donors. A preliminary experience. Transfusion 1986;26(4):309-14
Date
07/01/1986Pubmed ID
3523870DOI
10.1046/j.1537-2995.1986.26486262736.xScopus ID
2-s2.0-0022455407 (requires institutional sign-in at Scopus site) 41 CitationsAbstract
Seven hundred and sixty-three blood donors previously typed for HLA-A and B antigens were asked to consider donating bone marrow to unrelated patients for whom no HLA-matched sibling was available. Eighty-eight percent (668) indicated willingness to donate marrow, and of these, 615 (81%) participated in testing and 53 (7%) were unable to participate at the time of the request. Donors matched for HLA-A, B, C, and DR antigens and compatible in the mixed-leukocyte culture reaction were identified for 12 patients and eight transplants were performed. Engraftment was successful in all eight patients. In this article the factors considered in planning the program, the protocol eventually developed, the problems encountered, and critical issues of informed consent and donor confidentiality are reviewed.
Author List
McElligott MC, Menitove JE, Aster RHMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Bone Marrow Transplantation
Child, Preschool
Family
Female
Follow-Up Studies
Health Resources
Histocompatibility Testing
Humans
Informed Consent
Male
Tissue Donors
Wisconsin
