Post-transfusion purpura associated with alloimmunization against the platelet-specific antigen, Baka. Am J Hematol 1986 Jan;21(1):79-88
Date
01/01/1986Pubmed ID
3754690DOI
10.1002/ajh.2830210110Scopus ID
2-s2.0-0022653456 (requires institutional sign-in at Scopus site) 47 CitationsAbstract
Post-transfusion purpura (PTP) with severe thrombocytopenia occurred eight days after transfusion in a 28-year-old woman and responded to treatment with prednisone and plasma exchange. In contrast to nearly all previously studied cases of PTP, the patient's platelets were PlA1-positive and anti-PlA1 antibody could not be detected in serum obtained during the thrombocytopenic episode. Her serum was found to contain an antibody specific for a recently described platelet-specific alloantigen, Baka, in addition to multiple HLA-specific antibodies. The patient's platelets, typed following recovery, were Baka-negative. These findings indicate that post-transfusion purpura can occur in association with alloimmunization to platelet-specific antigens other than PlA1. In performing the serologic studies, a close relationship and possible identity between Baka and another recently reported platelet antigen, Leka, was observed. A method for analyzing mixtures of cytotoxic platelet-reactive antibodies without separating the individual antibodies is described.
Author List
Keimowitz RM, Collins J, Davis K, Aster RHAuthor
Richard H. Aster MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAntigens, Human Platelet
Blood Group Incompatibility
Blood Platelets
Female
HLA Antigens
Humans
Integrin beta3
Isoantibodies
Isoantigens
Platelet Transfusion
Purpura, Thrombocytopenic
Time Factors
Transfusion Reaction
