Idiopathic (autoimmune) thrombocytopenic purpura with a complement-fixing autoantibody and response to plasma exchange. Scand J Haematol 1985 Nov;35(5):525-30
Date
11/01/1985Pubmed ID
4089531DOI
10.1111/j.1600-0609.1985.tb02823.xScopus ID
2-s2.0-0022396591 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
A 69-year-old male presented with severe, life-threatening thrombocytopenia, subsequently diagnosed as autoimmune thrombocytopenic purpura (ATP). A potent complement-activating platelet-specific autoantibody was present in the patient's serum. The IgG autoantibody induced lysis of autologous and isologous platelets but was nonreactive with red cells and lymphocytes. It reacted in an indirect immunofluorescence test with platelets from 50 control subjects and with thrombasthenic platelets but failed to react with platelets from a patient with the Bernard-Soulier syndrome (BSS), suggesting that it recognizes a glycoprotein absent from BSS platelets. Treatment by exchange transfusion and plasmapheresis was followed by disappearance of the autoantibody and sustained remission.
Author List
Szatkowski NS, Aster RHMESH terms used to index this publication - Major topics in bold
AgedAntigens
Autoantibodies
Autoimmune Diseases
Blood Platelets
Complement System Proteins
Exchange Transfusion, Whole Blood
Glycoproteins
Humans
Immunoglobulin G
Male
Plasmapheresis
Purpura, Thrombocytopenic
Thrombasthenia
