Immune thrombocytopenia associated with carcinoma. Ann Intern Med 1983 Oct;99(4):470-2
Date
10/01/1983Pubmed ID
6625379DOI
10.7326/0003-4819-99-4-470Scopus ID
2-s2.0-0020566566 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Both platelet-associated IgG and IgM were quantitatively determined before and after therapy for immune thrombocytopenia in three patients with a recent diagnosis of carcinoma. In one patient, the platelet-associated IgG normalized and the platelet-associated IgM improved after the thrombocytopenia resolved after treatment with steroids, a splenectomy, and a brief course of chemotherapy. In the second patient, the thrombocytopenia improved during treatment with steroids; after further treatment with steroids and chemotherapy, the platelet-associated IgG and IgM decreased. In a third patient who received no specific therapy, the platelet-associated IgG and IgM increased as the tumor progressed. Quantitation of platelet-associated IgG and IgM appears useful in determining which patients with thrombocytopenia and cancer may respond to therapy for immune thrombocytopenia. Patients who respond may then benefit from specific therapy against the primary malignancy.
Author List
Bellone JD, Kunicki TJ, Aster RHMESH terms used to index this publication - Major topics in bold
AdultAged
Blood Platelets
Carcinoembryonic Antigen
Carcinoma
Female
Humans
Immunoglobulin G
Immunoglobulin M
Male
Middle Aged
Platelet Count
Prednisone
Splenectomy
Thrombocytopenia
