Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expression. Infect Immun 2003 Mar;71(3):1109-15
Date
02/22/2003Pubmed ID
12595421Pubmed Central ID
PMC148886DOI
10.1128/IAI.71.3.1109-1115.2003Scopus ID
2-s2.0-0037372643 (requires institutional sign-in at Scopus site) 128 CitationsAbstract
Paneth cells, highly secretory epithelial cells found at the bases of small intestinal crypts, release a variety of microbicidal molecules, including alpha-defensins and lysozyme. The secretion of antimicrobials by Paneth cells is thought to be important in mucosal host defense against invasion by enteric pathogens. We explored whether enteric pathogens can interfere with this arm of defense. We found that oral inoculation of mice with wild-type Salmonella enterica serovar Typhimurium decreases the expression of alpha-defensins (called cryptdins in mice) and lysozyme. Oral inoculation with Salmonella serovar Typhimurium strains that are heat killed, lack the PhoP regulon, and lack the SPI1 type III secretion system or with Listeria monocytogenes does not have this effect. Salmonella may gain a specific survival advantage in the intestinal lumen by decreasing the expression of microbicidal peptides in Paneth cells through direct interactions between Salmonella and the small intestinal epithelium.
Author List
Salzman NH, Chou MM, de Jong H, Liu L, Porter EM, Paterson YAuthor
Nita H. Salzman MD, PhD Center Director, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnti-Bacterial Agents
Female
Intestinal Diseases
Intestine, Small
Mice
Mitogen-Activated Protein Kinases
Muramidase
Paneth Cells
Protein Precursors
RNA, Messenger
Salmonella Infections, Animal
Salmonella typhimurium
p38 Mitogen-Activated Protein Kinases
