Faculty Collaboration Database

Quantitative ultrasonic assessment of normal and ischaemic myocardium with an acoustic microscope: relationship to integrated backscatter. Cardiovasc Res 1990 Jun;24(6):447-55

Date

06/01/1990

Pubmed ID

2201447

DOI

10.1093/cvr/24.6.447

Scopus ID

2-s2.0-85047680114 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

PURPOSE OF INVESTIGATION: The aim was to study ultrasonic propagation properties of normal and ischaemic myocardium with a scanning laser acoustic microscope and to correlate these changes with ultrasonic backscatter.

DESIGN: Myocardial ischaemia was produced by total occlusion of left anterior descending coronary artery in anaesthetised open chest dogs. Myocardium supplied by left circumflex coronary artery served as normal control. IBR5, an optimum weighted frequency average (4-6.8 MHz) of the squared envelope of diffraction corrected backscatter, was measured in vivo. Ultrasonic attenuation coefficient, an index of loss per unit distance, the propagation speed and heterogeneity index were measured from normal and ischaemic regions with a scanning laser acoustic microscope which operates at 100MHz in vitro. Myocardial water content of normal and ischaemic myocardium was also estimated.

SUBJECTS: Were five anaesthetised mongrel dogs.

RESULTS: Attenuation coefficient of 33.8(SD4.2) dB.mm-1 in the ischaemic tissue was lower than 63.8(17.2) dB.mm-1 in the normal tissue (p less than 0.01). Ultrasonic speed was lower in ischaemic than normal myocardium at 1584(25) v 1612(35) m.s-1 (p less than 0.05). Heterogeneity index of 11(7) m.s-1 in the ischaemic region was lower than 14(8) m.s-1 in the normal region (27% reduction, p less than 0.05). IBR5 and myocardial water content were higher in the ischaemic than the normal myocardium: -37.2(SEM1.8) dB v -46.6(0.6) dB, (p less than 0.01) and 80.9(0.0)% v 78(0.2)%, (p less than 0.05) respectively.

CONCLUSION: Ultrasonic properties of the myocardium are significantly altered during acute ischaemia.

Author List

Sagar KB, Agemura DH, O'Brien WD Jr, Pelc LR, Rhyne TL, Wann LS, Komorowski RA, Warltier DC

MESH terms used to index this publication - Major topics in bold

Animals
Coronary Disease
Dogs
Female
Lasers
Male
Microscopy, Electron
Mitochondria, Heart
Myocardium
Myofibrils
Ultrasonography
Water