Regulation of expression of the Borrelia burgdorferi beta(3)-chain integrin ligand, P66, in ticks and in culture. Infect Immun 2003 Feb;71(2):1001-7
Date
01/24/2003Pubmed ID
12540584Pubmed Central ID
PMC145366DOI
10.1128/IAI.71.2.1001-1007.2003Scopus ID
2-s2.0-0037306601 (requires institutional sign-in at Scopus site) 45 CitationsAbstract
Borrelia burgdorferi is maintained in an infection cycle between mammalian and arthropod hosts. Appropriate gene expression by B. burgdorferi at different stages of this cycle is probably essential for transmission and establishment of infection. The B. burgdorferi beta(3) integrin ligand P66 is expressed by the bacteria in mammals, laboratory culture, and engorged but not unfed ticks. No in vitro culture conditions in which P66 expression reflected that in the unfed tick were found, suggesting that there are aspects of B. burgdorferi-tick interaction that remain unexplored.
Author List
Cugini C, Medrano M, Schwan TG, Coburn JAuthor
Jenifer Coburn PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBacterial Proteins
Borrelia burgdorferi
Culture Media
Feeding Behavior
Gene Expression Regulation, Bacterial
Hydrogen-Ion Concentration
Integrin beta3
Ixodes
Ligands
Mice
Porins
Temperature
