Evaluation of merocyanine 540-sensitized photoirradiation as a means to inactivate enveloped viruses in blood products. J Lab Clin Med 1990 Oct;116(4):439-47
Date
10/01/1990Pubmed ID
2170551Scopus ID
2-s2.0-44949287038 (requires institutional sign-in at Scopus site) 61 CitationsAbstract
Dry or wet heat, solvents, and detergents combined with ultraviolet irradiation provide effective means of sterilizing soluble blood products such as albumin or factor VIII. For obvious reasons, these procedures are not applicable to cellular blood components. We have recently shown that simultaneous exposure to the photosensitizer, merocyanine 540 (MC 540) and white light rapidly inactivates the Friend erythroleukemia virus complex and Friend virus-transformed cells, but causes relatively little damage to pluripotent hematopoietic stem cells. In this communication, we show that several lipid-enveloped human pathogenic viruses are also highly susceptible to MC 540-sensitized photoirradiation, and we report on an initial evaluation of the ability of MC 540-sensitized photoirradiation to sterilize blood products.
Author List
O'Brien JM, Montgomery RR, Burns WH, Gaffney DK, Sieber FAuthor
Fritz Sieber PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
2,3-DiphosphoglycerateAdenosine Triphosphate
Adenoviruses, Human
Animals
Antiviral Agents
Blood Transfusion
Cell Line
Cytomegalovirus
Diphosphoglyceric Acids
Erythrocytes
Human T-lymphotropic virus 1
Humans
In Vitro Techniques
Kinetics
Light
Pyrimidinones
Radiation-Sensitizing Agents
Simplexvirus
