Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. J Clin Invest 1996 Jan 15;97(2):522-7
Date
01/15/1996Pubmed ID
8567976Pubmed Central ID
PMC507046DOI
10.1172/JCI118444Scopus ID
2-s2.0-13344276589 (requires institutional sign-in at Scopus site) 50 CitationsAbstract
To investigate whether a BP-regulatory locus exists in the vicinity of the renin locus on rat chromosome 13, we transferred this chromosome segment from the Dahl salt-sensitive (S) rat onto the genetic background of the Dahl salt-resistant (R) rat. In congenic Dahl R rats carrying the S renin gene and fed an 8% salt diet, systolic BP was significantly lower than in progenitor Dahl R rats: 127 +/- 1 mmHg versus 138 +/- 4 mmHg, respectively (P < 0.05). Moreover, the decreased BP in the congenic Dahl R strain was associated with decreased kidney renin mRNA and decreased plasma renin concentration. These findings demonstrate that the Dahl S strain carries alleles in or near the renin locus that confer lower plasma renin concentration and lower BP than the corresponding alleles in the Dahl R strain, at least when studied on the genetic background of the Dahl R rat and in the environment of a high salt diet. The occurrence of coincident reductions in kidney renin mRNA, plasma renin concentration, and BP after interstrain transfer of naturally occurring renin gene variants strongly suggests that genetically determined variation in renin gene expression can affect BP.
Author List
St Lezin EM, Pravenec M, Wong AL, Liu W, Wang N, Lu S, Jacob HJ, Roman RJ, Stec DE, Wang JM, Reid IA, Kurtz TWMESH terms used to index this publication - Major topics in bold
AllelesAnimals
Chromosome Mapping
Diet
Female
Gene Expression Regulation, Enzymologic
Genetic Markers
Hypertension
Kidney
Male
RNA, Messenger
Rats
Rats, Inbred Strains
Rats, Mutant Strains
Renin
Sodium Chloride, Dietary
