Faculty Collaboration Database

Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells. Biomaterials 2008 Apr;29(10):1431-42

Date

01/15/2008

Pubmed ID

18191190

DOI

10.1016/j.biomaterials.2007.11.026

Scopus ID

2-s2.0-38349140685 (requires institutional sign-in at Scopus site)   164 Citations

Abstract

The aim of the present study was to evaluate the potential of acellular dermal matrix as a carrier for delivery of stem cells to the site of soft tissue defect in a murine skin injury model and to determine the potential of stem cells delivered via such an approach to successfully engraft, survive and differentiate locally. We showed that adipose-derived stem cells delivered via this matrix survived after in vivo engraftment, spontaneously differentiated along vascular endothelial, fibroblastic and epidermal epithelial lineages and significantly improved wound healing. Furthermore, an organ survey for transplanted cells showed no evidence of a systemic distribution beyond the cutaneous wound site, indicating that the adipose-derived stem cell-dermal matrix construct provides a novel and effective method for anatomically focused cellular therapy. In conclusion, stem cell-seeded dermal matrix is an effective means for targeted in vivo cell delivery for enhanced soft tissue regeneration.

Author List

Altman AM, Matthias N, Yan Y, Song YH, Bai X, Chiu ES, Slakey DP, Alt EU

Author

Xiaowen Bai PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adipose Tissue
Animals
Dermis
Extracellular Matrix
Flow Cytometry
Fluorescent Antibody Technique
Humans
Mice
Stem Cell Transplantation
Stem Cells