Sequelae of cryotherapy in breast tissue. Cryobiology 2003 Oct;47(2):174-8
Date
10/29/2003Pubmed ID
14580851DOI
10.1016/j.cryobiol.2003.09.002Scopus ID
2-s2.0-0142168979 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Cryotherapy is a novel treatment for benign and malignant breast lesions that is under evaluation. We assessed the acute and subacute outcomes of breast cryotherapy in normal goat teats using physical, microscopic, and imaging modalities. Eight goats were subjected to two freeze-thaw cycles of breast tissue producing a 2cm iceball and sacrificed either 2 or 7 weeks later. Acute skin changes were minimal unless obvious tissue injury occurred during cryotherapy; however, depigmentation developed over several weeks in dark-skinned goats despite the presence of melanocytes. By histology, breast epithelial elements could not be identified at cryotherapy sites. There was no cystic degeneration, which is common at surgical excision sites. Neither calcifications nor prominent scarring could be attributed to cryotherapy on imaging studies after 2 or 7 weeks. When compared to standard breast surgery, the sequelae of cryotherapy using histologic, radiographic, and sonographic criteria were decreased. Our study suggests that cryotherapy, with technical modifications, is feasible within breast tissue and warrants further study.
Author List
Otterson MF, Redlich PN, McDonald A, Kristin Thorsen M, Klaas KK, Clowry LJ, Walker APAuthor
Philip N. Redlich MD, PhD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCryosurgery
Cryotherapy
Female
Freezing
Goats
Mammary Glands, Animal
Mammary Neoplasms, Animal
Mammography
Melanocytes
Pigmentation
Skin
Temperature
Time Factors
Ultrasonics
