Physiology and pathophysiology of glottic reflexes and pulmonary aspiration: from neonates to adults. Semin Respir Crit Care Med 2010 Oct;31(5):554-60
Date
10/14/2010Pubmed ID
20941656Pubmed Central ID
PMC3796769DOI
10.1055/s-0030-1265896Scopus ID
2-s2.0-77958131878 (requires institutional sign-in at Scopus site) 39 CitationsAbstract
Pulmonary aspiration is the consequence of abnormal entry of fluid, particulate material, or endogenous secretions into the airway. The two main types of aspiration scenarios include anterograde aspiration, which occurs during swallowing, and retrograde aspiration, which can occur during gastroesophageal reflux (GER) events. The important structures that protect against aspiration include the aerodigestive apparatus: pharynx, upper esophageal sphincter, esophageal body, glottis and vocal cords, and airway. In this article we review the neuroanatomy, physiology, and pathophysiology pertinent to glottic reflexes and airway aspiration across the age spectrum from neonates to adults. We also discuss recent advances in our understanding of glottal reflexes and the relationship of these reflexes to developmental anatomy and physiology, the pathophysiology of aspiration, and aerodigestive interactions.
Author List
Jadcherla SR, Hogan WJ, Shaker RAuthor
Reza Shaker MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aging
Child
Child, Preschool
Deglutition Disorders
Gastroesophageal Reflux
Glottis
Humans
Infant
Infant, Newborn
Respiratory Aspiration
Young Adult
