Impact of female hormones on blood pressure: review of potential mechanisms and clinical studies. Curr Hypertens Rep 2003 Dec;5(6):505-12
Date
11/05/2003Pubmed ID
14594572DOI
10.1007/s11906-003-0059-0Scopus ID
2-s2.0-3142516293 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
In recent studies, it has been found that postmenopausal hormonal therapy is associated with an increased incidence of cardiovascular disease. Experimental studies suggest several potential mechanisms by which estrogens might decrease blood pressures, and estrogen administration attenuates hypertension in several animal models. In humans, although oral contraceptive agents are frequently associated with increases in blood pressure, blood pressure was not increased or was minimally increased in prospective clinical trials of hormone therapy in postmenopausal women. These observations suggest that the excess rates of cardiovascular disease are not caused by increased blood pressure.
Author List
Morley Kotchen J, Kotchen TAMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Cardiovascular Diseases
Contraceptive Agents, Female
Endothelium, Vascular
Estrogen Replacement Therapy
Estrogens
Female
Hormones
Humans
Male
Muscle, Smooth, Vascular
Progesterone
Risk Assessment
Vascular Resistance
