Efficacy of laryngeal botulinum toxin injection: comparison of two techniques. Laryngoscope 2011 Sep;121(9):1924-8
Date
10/26/2011Pubmed ID
22024846Pubmed Central ID
PMC3202690DOI
10.1002/lary.21966Scopus ID
2-s2.0-80052087153 (requires institutional sign-in at Scopus site) 25 CitationsAbstract
OBJECTIVES/HYPOTHESIS: It is hypothesized that there is no difference in the effectiveness of botulinum toxin (BTX) injection between electromyography (EMG)-guided and non-EMG guided "point-touch" techniques in the treatment of adductor spasmodic dysphonia.
STUDY DESIGN: Retrospective chart review.
METHODS: Patients selected for evaluation underwent sequential treatment by one or both of the senior authors using two different injection techniques with similar BTX dilution and preparation. Data gathered included dose injected, injection effect, and presence and duration of breathiness and dysphagia after injection. Statistical analysis was performed used a generalized estimating equations model.
RESULTS: A total of 417 injections in 64 patients were analyzed. There was no difference in the rate of successful injections between the EMG-guidance group and the non-EMG guidance group (94.4% and 93.2%, respectively; P = .7).
CONCLUSIONS: This unique study demonstrates that efficacy of BTX does not necessarily depend on the method of injection used. In experienced hands, excellent clinical results can be achieved with either EMG-guided or non-EMG guided injection techniques.
Author List
Fulmer SL, Merati AL, Blumin JHAuthor
Joel H. Blumin MD Chief, Professor in the Otolaryngology and Communication Sciences department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Botulinum Toxins, Type AElectromyography
Female
Humans
Injections
Male
Middle Aged
Neuromuscular Agents
Retrospective Studies
Treatment Outcome
Voice Disorders
