Faculty Collaboration Database

Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol 2001 Mar 01;114(1-2):107-13

Date

03/10/2001

Pubmed ID

11240021

DOI

10.1016/s0165-5728(00)00459-8

Scopus ID

2-s2.0-0035283401 (requires institutional sign-in at Scopus site)   169 Citations

Abstract

Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endogenous apoE on inflammatory gene regulation in vitro and in vivo. Our results indicate that apoE downregulates CNS production of TNFalpha, Il-1beta, and Il-6 mRNA following stimulation with lipopolysaccharide (LPS). This effect of endogenous apoE on inflammatory gene regulation appears to be specific, and may account for the biological role that apoE plays in acute and chronic human neurological disease.

Author List

Lynch JR, Morgan D, Mance J, Matthew WD, Laskowitz DT

MESH terms used to index this publication - Major topics in bold

Animals
Apolipoproteins E
Brain
Cells, Cultured
Encephalitis
Gene Expression
Interleukin-1
Interleukin-6
Lipopolysaccharides
Male
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Microglia
RNA, Messenger
Tumor Necrosis Factor-alpha