Faculty Collaboration Database

Comparison of arterial blood pressure in different strains of mice. Am J Hypertens 2001 May;14(5 Pt 1):405-8

Date

05/23/2001

Pubmed ID

11368457

DOI

10.1016/s0895-7061(00)01285-1

Scopus ID

2-s2.0-0035024490 (requires institutional sign-in at Scopus site)   86 Citations

Abstract

The present study was performed to compare the resting level of arterial blood pressure when monitored for 24 h/day in outbred Swiss Webster (SW) and inbred C57BL/ 6J, A/J, C3HeB/FeJ, and SWR/J mice. Mean arterial pressure (MAP) and heart rate (HR) varied throughout the day, with maximal values observed in the hours of darkness. Systolic (SAP), MAP, and diastolic (DAP) arterial blood pressure averaged 122 +/- 2, 112 +/- 2, and 102 +/- 2 mm Hg, respectively, in conscious SW mice (N = 6). No differences were detected in the 24-h averages of MAP between SW, C57BL/6J (N = 7), A/J (N = 5), C3HeB/FeJ (N = 5), or SWR/J (N = 7) mice maintained on a normal sodium diet. Average daily heart rate (HR) was highest in the C3HeB/FeJ (665 +/- 15 beats/min) and lowest in the C57BL/6J (594 +/- 9 beats/min). The MAP was significantly increased in SW mice administered L-NAME (133 +/- 2 mm Hg, N = 5) and significantly decreased in SW mice administered captopril (99 +/- 2 mm Hg, N = 5). These studies demonstrate similar levels of resting arterial pressure in different mouse strains under baseline conditions.

Author List

Mattson DL

MESH terms used to index this publication - Major topics in bold

Animals
Animals, Outbred Strains
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Catheterization
Enzyme Inhibitors
Heart Rate
Hypertension
Male
Mice
Mice, Inbred Strains
NG-Nitroarginine Methyl Ester
Rest