Faculty Collaboration Database

Role of the renin-angiotensin system during alterations of sodium intake in conscious mice. Am J Physiol Regul Integr Comp Physiol 2001 Sep;281(3):R987-93

Date

08/17/2001

Pubmed ID

11507017

DOI

10.1152/ajpregu.2001.281.3.R987

Scopus ID

2-s2.0-0034826622 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

The present studies were performed to quantify circulating components of the renin-angiotensin-aldosterone axis and to determine the functional importance of this system during alterations in sodium intake in conscious mice. Increasing sodium intake from approximately 200 to 1,000 microeq/day significantly decreased plasma renin concentration from 472 +/- 96 to 304 +/- 83 ng ANG I. ml(-1). h(-1) (n = 5) but did not alter plasma renin activity from the low-sodium level of 7.7 +/- 1.1 ng ANG I. ml(-1). h(-1). Despite the elevated plasma renin concentration, plasma ANG II in mice on low-sodium level averaged 14 +/- 3 pg/ml and was significantly suppressed to 6 +/- 1 pg/ml by high-sodium intake (n = 7). Consistent with the modulation of ANG II, plasma aldosterone significantly decreased from 41 +/- 8 to 8 +/- 3 ng/dl when sodium intake was elevated (n = 6). In a final set of experiments, the continuous infusion of ANG II (20 ng. kg(-1). min(-1)) led to a mild salt-sensitive increase in mean arterial pressure from 108 +/- 2 to 131 +/- 2 mmHg as sodium intake was varied from low to high (n = 7). In vehicle-infused mice, mean arterial pressure was unaltered from 109 +/- 2 mmHg when sodium intake was increased (n = 6). These studies indicate that the physiological suppression of circulating ANG II may be required to maintain a constancy of arterial pressure during alterations in sodium intake in normal mice.

Author List

Cholewa BC, Mattson DL

MESH terms used to index this publication - Major topics in bold

Aldosterone
Angiotensin II
Animals
Blood Pressure
Consciousness
Creatinine
Electrolytes
Furosemide
Infusions, Intravenous
Injections, Intravenous
Male
Mice
Potassium
Renin
Renin-Angiotensin System
Sodium
Sodium, Dietary