Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis. Mol Carcinog 2013 Jan;52(1):49-56
Date
11/17/2011Pubmed ID
22086836DOI
10.1002/mc.20877Scopus ID
2-s2.0-84871344756 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
In this study, we evaluated chemopreventive efficacy of Antitumor B, a Chinese herbal mixture of six plants (Sophora tonkinensis, Polygonum bistorta, Prunella vulgaris, Sonchus arvensis L., Dictamnus dasycarpus, and Dioscorea bulbifera) on the development of 4-nitroquinoline-1-oxide (4NQO) induced oral squamous cell carcinomas in A/J mice. Antitumor B, delivered through diet, inhibited 4NQO-induced oral cancer development by 59.19%. The reduction of cell proliferation appears to be associated with efficacy of Antitumor B against 4NQO-induced oral cancer in A/J mice. The expression of epidermal growth factor receptor (EGFR) and phosphorylated EGFR (Tyr1173) were down-regulated by Antitumor B. Tissue distribution of Antitumor B was determined using obacunone, matrine, and maackiain as marker chemicals. We found significant amounts of obacunone, matrine, and maackiain in the blood after 1-wk treatment. The concentrations of these three compounds did not increase further at 18 wk, suggesting that plasma concentrations had reached a steady-state level at 1 wk. There was no significant body weight loss and there was no other obvious sign of toxicity in Antitumor B-treated mice. These results suggest that Antitumor B is a promising agent for human oral cancer chemoprevention.
Author List
Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E, Hu M, Lubet RA, You MMESH terms used to index this publication - Major topics in bold
4-Nitroquinoline-1-oxideAlkaloids
Animals
Antineoplastic Agents, Phytogenic
Benzoxepins
Biomarkers
Carcinogens
Carcinoma, Squamous Cell
Cell Proliferation
Cell Transformation, Neoplastic
Chemoprevention
Drugs, Chinese Herbal
ErbB Receptors
Limonins
Male
Mice
Mouth Neoplasms
Phosphorylation
Pterocarpans
Quinolizines
Tyrosine
