Drug-induced hypersensitivity syndrome in pediatric patients. Pediatrics 2001 Aug;108(2):485-92
Date
08/03/2001Pubmed ID
11483822DOI
10.1542/peds.108.2.485Scopus ID
2-s2.0-0034886527 (requires institutional sign-in at Scopus site) 103 CitationsAbstract
The antiepileptic hypersensitivity syndrome is a severe, multiorgan reaction to oral antiepileptics that manifests as fever, rash, lymphadenopathy, and hepatitis. This same reaction pattern also has been described following administration of a few unrelated medications. We report on 11 patients who had drug-induced hypersensitivity syndrome and were admitted to our pediatric service and review 94 cases of this syndrome in pediatric patients identified from the literature. We undertook this study to summarize the findings and alert clinicians to the severe internal organ involvement that can occur with this syndrome.
Author List
Carroll MC, Yueng-Yue KA, Esterly NB, Drolet BAMESH terms used to index this publication - Major topics in bold
AdolescentAge Factors
Anticonvulsants
Child
Child, Preschool
Diagnosis, Differential
Drug Eruptions
Drug Hypersensitivity
Drug-Related Side Effects and Adverse Reactions
Female
Humans
Infant
Male
Mucous Membrane
Pediatrics
Skin
Syndrome
