Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons. Neuroreport 2001 Oct 08;12(14):3033-7
Date
09/25/2001Pubmed ID
11568632DOI
10.1097/00001756-200110080-00011Scopus ID
2-s2.0-0035828995 (requires institutional sign-in at Scopus site) 142 CitationsAbstract
Light close to and in the near-infrared range has documented benefits for promoting wound healing in human and animals. However, mechanisms of its action on cells are poorly understood. We hypothesized that light treatment with a light-emitting diode array at 670 nm (LED) is therapeutic in stimulating cellular events involving increases in cytochrome oxidase activity. LED was administered to cultured primary neurons whose voltage-dependent sodium channels were blocked by tetrodotoxin. The down-regulation of cytochrome oxidase activity by TTX was reverted to control levels by LED. LED alone also up-regulated enzyme activity. Thus, the results are consistent with our hypothesis that LED has a stimulating effect on cytochrome oxidase in neurons, even when they have been functionally silenced by TTX.
Author List
Wong-Riley MT, Bai X, Buchmann E, Whelan HTMESH terms used to index this publication - Major topics in bold
AgingAnimals
Animals, Newborn
Cells, Cultured
Dose-Response Relationship, Drug
Down-Regulation
Electron Transport Complex IV
Infrared Rays
Nerve Degeneration
Neurons
Photic Stimulation
Rats
Sodium Channel Blockers
Sodium Channels
Tetrodotoxin
Visual Cortex
Wound Healing
