Proliferation and regeneration of retrogradely labeled adult rat corticospinal neurons in culture. Exp Neurol 2001 Aug;170(2):277-82
Date
07/31/2001Pubmed ID
11476593DOI
10.1006/exnr.2001.7705Scopus ID
2-s2.0-0034869214 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
These are the first studies to demonstrate that adult rat corticospinal tract (CST) neurons, which were identified by retrograde neuronal labeling, retain regenerative and proliferative potential. To determine if adult CST neurons undergo cell division, we tested if these retrogradely labeled cells synthesize DNA by adding BrdU to the cultures 24 h prior to fixation of the cells. The result shows that adult corticospinal tract neurons are capable of DNA synthesis, and our total cell counts with labeled cells counts further suggest that these cells undergo cell division.
Author List
Alexanian AR, Nornes HOAuthor
Arshak R. Alexanian VMD, PhD Adjunct Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAxonal Transport
Bromodeoxyuridine
Cell Division
Cell Survival
Cells, Cultured
DNA
Immunohistochemistry
Kinetics
Male
Nerve Regeneration
Neurites
Neurons
Pyramidal Tracts
Rats
Rats, Sprague-Dawley
Time Factors
