Models of cardiac ischemia-reperfusion injury in dogs and rats. Curr Protoc Pharmacol 2002 May 01;Chapter 5:Unit 5.27
Date
05/01/2002Pubmed ID
22294078DOI
10.1002/0471141755.ph0527s16Scopus ID
2-s2.0-84858855617 (requires institutional sign-in at Scopus site) 1 CitationAbstract
A marked reduction in coronary blood flow produces a reduction in myocardial function, electrocardiographic abnormalities and eventually a myocardial infarction if the ischemic episode were to persist for more than 20 to 30 min. There have been numerous studies in animal models in search of a magic bullet or drug that can ameliorate these symptoms and result in a reduction in infarct size, improvement in the recovery of contractile function, and abrogation of malignant ventricular arrhythmias in humans. This unit describes two animal models of myocardial ischemia/reperfusion injury which are used to evaluate pharmacological agents that may eventually demonstrate cardioprotective activity in a clinical setting.
Author List
Gross GJMESH terms used to index this publication - Major topics in bold
AnimalsColoring Agents
Coronary Circulation
Disease Models, Animal
Dogs
Female
Male
Myocardial Reperfusion Injury
Myocardium
Rats
Rats, Sprague-Dawley
Rats, Wistar
Tetrazolium Salts
