No association of germline alteration of MSR1 with prostate cancer risk. Nat Genet 2003 Oct;35(2):128-9
Date
09/06/2003Pubmed ID
12958598DOI
10.1038/ng1239Scopus ID
2-s2.0-0141507056 (requires institutional sign-in at Scopus site) 49 CitationsAbstract
The macrophage scavenger receptor 1 gene (MSR1) was recently identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer. To confirm these findings, we screened MSR1 for germline mutations among individuals with familial prostate cancer and tested gene variants for associations in both sporadic and familial prostate cancer. Our results do not support MSR1 as a risk factor for prostate cancer.
Author List
Wang L, McDonnell SK, Cunningham JM, Hebbring S, Jacobsen SJ, Cerhan JR, Slager SL, Blute ML, Schaid DJ, Thibodeau SNMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Genetic Variation
Germ-Line Mutation
Humans
Male
Middle Aged
Molecular Sequence Data
Prostate-Specific Antigen
Prostatic Neoplasms
Receptors, Immunologic
Receptors, Scavenger
Reference Values
Risk Factors
Scavenger Receptors, Class A
