Comparative effects of nicorandil, nitroglycerin, nicotinic acid, and SG-86 on the metabolic status and functional recovery of the ischemic-reperfused myocardium. J Cardiovasc Pharmacol 1987;10 Suppl 8:S76-84
Date
01/01/1987Pubmed ID
2447429Scopus ID
2-s2.0-0023518719 (requires institutional sign-in at Scopus site) 25 CitationsAbstract
The effects of nicorandil (SG-75), its major metabolite (SG-86), nitroglycerin, and nicotinic acid on myocardial segment shortening (% SS) and velocity of shortening (dL/dt, mm/s) were compared with those of a control group during 15 min of coronary occlusion followed by 3 h of reperfusion in anesthetized dogs. Piezoelectric crystals were used to measure % SS and dL/dt in regions perfused by the left anterior descending (LAD) and left circumflex (LC) coronary arteries. The radioactive microsphere technique was used to measure regional myocardial blood flow, and arterial and coronary sinus blood samples were obtained for the determination of glucose and free fatty acids. All drugs were administered intravenously 30 min before and throughout the occlusion period. Nicorandil (25 micrograms/kg/min) and nitroglycerin (3 micrograms/kg/min) produced nearly equivalent reductions in the heart rate-systolic pressure product. Nicotinic acid (0.3 mg/kg/min) and SG-86 (50 micrograms/kg/min) had no hemodynamic effects. Nicotinic acid reduced free fatty acid uptake during occlusion and at 30 min of reperfusion, whereas the other three agents had no major effects on substrate utilization. During occlusion, % SS in the ischemic region was severely depressed; collateral blood flow was similar in each series. However, during reperfusion, the nicorandil- and nicotinic acid-treated animals showed a marked improvement in % SS and dL/dt, as compared with those treated with saline (control), nitroglycerin, or SG-86. The mechanism(s) responsible for the beneficial actions of nicotinic acid and nicorandil in this model are unknown but may be partially related to the effect of nicotinic acid to reduce fatty acid uptake by the ischemic myocardium and the peripheral hemodynamic actions of nicorandil.
Author List
Gross GJ, Pieper GM, Warltier DCMESH terms used to index this publication - Major topics in bold
AnimalsCoronary Circulation
Coronary Disease
Dogs
Fatty Acids, Nonesterified
Female
Glucose
Heart
Hemodynamics
Male
Myocardial Contraction
Myocardium
Niacin
Niacinamide
Nicorandil
Nitroglycerin
Perfusion
Vasodilator Agents
