Faculty Collaboration Database

Differential effect of isoflurane, medetomidine, and urethane on BOLD responses to acute levo-tetrahydropalmatine in the rat. Magn Reson Med 2012 Aug;68(2):552-9

Date

01/04/2012

Pubmed ID

22213080

Pubmed Central ID

PMC3376170

DOI

10.1002/mrm.23243

Scopus ID

2-s2.0-84863843999 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

Levo-tetrahydropalmatine (l-THP) has shown significant promise in preclinical and clinical studies to treat drug addiction. Pharmacological MRI methods can elucidate the regional cerebral effects of l-THP, but there are potential confounds from the use of general anesthesia. To investigate the possible anesthetic-drug interactions for the pharmacological MRI result of acute l-THP, we examined acute blood oxygen level-dependent responses of both 5 and 20 mg/kg l-THP in naïve rats during general anesthesia achieved with three agents: isoflurane, medetomidine, and urethane. We found that with acute l-THP administration, isoflurane revealed the smallest blood oxygen level-dependent activation areas. In addition, urethane had the most activation areas; however, they were all negative. Medetomidine showed mixed positive and negative activations. Region-specific interactions were found between the l-THP-induced blood oxygen level-dependent responses and the anesthetic agents.

Author List

Liu X, Li R, Yang Z, Hudetz AG, Li SJ

MESH terms used to index this publication - Major topics in bold

Anesthetics, General
Animals
Berberine Alkaloids
Blood Flow Velocity
Cerebrovascular Circulation
Drug Interactions
Magnetic Resonance Imaging
Male
Oxygen Consumption
Rats
Rats, Sprague-Dawley