Parenteral nutrition-associated cholestasis: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review. J Pediatr Surg 2012 Jan;47(1):225-40
Date
01/17/2012Pubmed ID
22244423DOI
10.1016/j.jpedsurg.2011.10.007Scopus ID
2-s2.0-84855845481 (requires institutional sign-in at Scopus site) 126 CitationsAbstract
OBJECTIVE: The aim of this study was to review evidence-based data addressing key clinical questions regarding parenteral nutrition-associated cholestasis (PNAC) and parenteral nutrition-associated liver disease (PNALD) in children.
DATA SOURCE: Data were obtained from PubMed, Medicine databases of the English literature (up to October 2010), and the Cochrane Database of Systematic Reviews.
STUDY SELECTION: The review of PNAC/PNALD has been divided into 4 areas to simplify one's understanding of the current knowledge regarding the pathogenesis and treatment of this disease: (1) nonnutrient risk factors associated with PNAC, (2) PNAC and lipid emulsions, (3) nutritional (nonlipid) considerations in the prevention of PNAC, and (4) supplemental medications in the prevention and treatment of PNAC.
RESULTS: The data for each topic area relevant to the clinical practice of pediatric surgery were reviewed, evaluated, graded, and summarized.
CONCLUSIONS: Although the conditions of PNAC and PNALD have been well recognized for more than 30 years, only a few concrete associations and treatment protocols have been established.
Author List
Rangel SJ, Calkins CM, Cowles RA, Barnhart DC, Huang EY, Abdullah F, Arca MJ, Teitelbaum DH, 2011 American Pediatric Surgical Association Outcomes and Clinical Trials CommitteeAuthor
Casey Matthew Calkins MD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ChildChild Nutritional Physiological Phenomena
Cholestasis
Evidence-Based Medicine
Fat Emulsions, Intravenous
Humans
Incidence
Parenteral Nutrition
Risk Factors
Severity of Illness Index
