Faculty Collaboration Database

A modified end-to-side method for peripheral nerve repair: large epineurial window helicoid technique versus small epineurial window standard end-to-side technique. J Hand Surg Am 2002 May;27(3):484-92

Date

05/17/2002

Pubmed ID

12015724

DOI

10.1053/jhsu.2002.32953

Scopus ID

2-s2.0-0036091982 (requires institutional sign-in at Scopus site)   61 Citations

Abstract

This study evaluated 2 end-to-side nerve repair techniques for ability to induce nerve sprouting and muscular recovery. Twenty-four rats underwent identical surgeries. The helicoid method of neurorrhaphy was used on the left (large epineurial window) side and the standard end-to-side (small epineurial window) repair on the right side of each rat to repair the peroneal nerve. The helicoid configuration markedly increases the area from which axons can sprout into the recipient nerve. At 11 months after surgery, axons were counted in donor and recipient nerves, and muscle moist weight of the extensor digitorum longus (EDL) and tetanic force were measured. Muscle volume, tetanic force, and moist weight of EDL muscles were significantly higher on the left side (helicoid) than on the right (end-to-side). Histologic analysis and nerve axon counting of the recipient peroneal nerve showed significantly more regenerative nerves on the left than on the right. There were no significant differences between sites above and below the repair site in the donor tibial nerve in regard to mean number of nerve fibers. Helicoid nerve repair can entice more nerve fiber sprouts from the intact donor nerve, improve muscular recovery, and maintain donor nerve health.

Author List

Yan JG, Matloub HS, Sanger JR, Zhang LL, Riley DA, Jaradeh SS

Author

James R. Sanger MD Professor in the Plastic Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anastomosis, Surgical
Animals
Disease Models, Animal
Immunohistochemistry
Male
Nerve Fibers
Nerve Regeneration
Neurosurgery
Peripheral Nervous System Diseases
Peroneal Nerve
Rats
Rats, Sprague-Dawley
Sciatic Nerve
Sensitivity and Specificity
Tibial Nerve