Faculty Collaboration Database

The depiction of brown adipose tissue is related to disease status in pediatric patients with lymphoma. AJR Am J Roentgenol 2012 Apr;198(4):909-13

Date

03/28/2012

Pubmed ID

22451560

DOI

10.2214/AJR.11.7488

Scopus ID

2-s2.0-84859145977 (requires institutional sign-in at Scopus site)   24 Citations

Abstract

OBJECTIVE: The objective of our study was to determine whether the depiction of brown adipose tissue (BAT) in PET/CT studies of pediatric patients with lymphoma is related to disease status.

MATERIALS AND METHODS: The PET/CT studies of 31 pediatric patients (17 boys and 14 girls) with Hodgkin or non-Hodgkin lymphoma were reviewed, and the prevalence of metabolically active BAT at diagnosis and the prevalence of BAT when there was no evidence of disease were compared.

RESULTS: The percentage of PET/CT studies depicting BAT was greater when there was no evidence of disease than at diagnosis (10% vs 77%, respectively; p < 0.001). The McNemar test indicated a strong inverse correlation between the presence of disease and the presence of BAT (p < 0.001). This correlation was noted when all subjects were examined together and when subjects with Hodgkin lymphoma and those with non-Hodgkin lymphoma were analyzed separately (p < 0.001 and < 0.05, respectively). When baseline and follow-up PET/CT scans for all patients were analyzed for the presence of BAT using conditional logistic regression, both the season when the study was performed and disease status independently predicted BAT: The winter months positively predicted BAT and the presence of lymphoma was negatively correlated with the depiction of BAT on PET/CT. Age, sex, treatment, and weight did not provide additional information when added to the model.

CONCLUSION: The knowledge that BAT is a predictor of disease status should contribute to the correct analysis of PET/CT studies in children with lymphoma.

Author List

Gilsanz V, Hu HH, Smith ML, Goodarzian F, Carcich SL, Warburton NM, Malogolowkin M

MESH terms used to index this publication - Major topics in bold

Adipose Tissue, Brown
Adolescent
Chi-Square Distribution
Child
Child, Preschool
Contrast Media
Diatrizoate Meglumine
Female
Humans
Logistic Models
Lymphoma
Male
Multimodal Imaging
Positron-Emission Tomography
Retrospective Studies
Tomography, X-Ray Computed